MicroNIR PAT-U

A fit-for-purpose near-infrared (NIR) analyzer for quality-by-design (QbD) manufacturing

The MicroNIR™ PAT-U is a USB-powered rugged NIR spectrometer. It is the smallest of its kind on the market making it suitable for use on equipment of different sizes as well as implementation of multiple of the analyzers on a given process.

MicroNIR PAT-U

The new MicroNIR PAT-U process spectrometer is a spectrometer innovation from the company. It is a scalable, sturdy next-generation system for real-time process monitoring in pharmaceutical and food process analytical technology (PAT) applications. With proven Viavi linear variable filter (LVF) technology, the PAT-U is recognized to have the smallest form factor on the market in a fit-for-purpose design. This makes it ideal for application with processing equipment of all sizes, with stability and the performance to facilitate efficient manufacturing.

The MicroNIR PAT-U can be used in an easy manner and was designed for the present-day demanding GMP-regulated environments; however it still needs marginal system maintenance. There are no moving components or expensive fiber optic cables, enabling excellent instrument stability and performance in challenging process environments. Its stainless steel exterior is water and dust resistant according to IP65 standards and cleans easily.

Key Features

The key features of the new MicroNIR PAT-U process spectrometer are listed below:

  • Compact for effortless integration
  • USB communication
  • Non-invasive, real-time NIR analysis
  • Washable, IP67 rated enclosure

Applications

The main applications of the new MicroNIR PAT-U process spectrometer are listed below:

  • Pharmaceutical manufacturing
    • Granulation
    • Fluid bed drying
    • Content uniformity
  • Food and feed manufacturing
    • Fat
    • Moisture content
    • Protein
    • Nutritional assay
  • Industrial processing
    • Polymers
    • Reaction monitoring
    • Petrochemicals

MicroNIR Software

The software package allows deployment flexibility from process/product development to manufacturing environments and offers encrypted secure data storage, audit trails, comprehensive user management and numerous other capabilities required for regulated GMP environments.

  • The instrument control software enables uncomplicated data acquisition, user management, real-time analysis, method development, method investigation, and instrument qualification per USP 1119 criteria
  • The Viavi Unscrambler® X Lite regression and classification software provides a full set of chemometric tools for data investigation and calibration model development
  • The MicroNIR Process software is programmed for easy process monitoring of varied process techniques from a variety of MicroNIR spectrometers. Process engineers can smoothly view acquired data and trend results in real-time with concurrent output of key process data to the plant control system.

Mounting and Process Integration

The MicroNIR PAT-U is engineered to guarantee highest flexibility to meet the many varied criteria for process integration. It adds into a process with different mounts.

Standard

The standard mount includes a weld in base flange, a 2” sanitary (hygienic) flange mount, a sapphire window, and a retaining ring with O-rings. The base flange is welded into a hole cut in the specific process equipment. Next, the window, the sanitary flange mount, and retaining ring are assembled. The PAT-U with a modifiable collet then secures against a sanitary flange and the window using a standard tri-clover clamp (or C-clamp). All pieces can be dismantled for easy cleaning and maintenance.

Threaded

The threaded mount allows a user to weld a mount into the process equipment and then link the PAT-U using the threaded tip of the spectrometer. This mount also has a removable window to allow easy cleaning and maintenance.

MicroNIR PAT-U
MicroNIR PAT-U

Standard mount

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Technical Specs

Parameter

Specification

Illumination source

Two integrated vacuum tungsten lamps

Bulb life

>40,000 hours

Illumination geometry

Flood illumination/ 0° observer

Input aperture dimensions

2.5 x 3.0 mm

Sample working distance

0 – 15 mm from window

Dispersing element

Linear variable filter

Detector

128-pixel InGaAs photodiode array

Pixel size/pitch

30 µm x 250 µm/50 µm

Wavelength range

950 – 1650 nm (10,526 – 6060 cm-1)

Pixel-to-pixel interval

6.2 nm for 950 – 1650 nm

Spectral bandwidth (FWHM)

<1.25% of center wavelength (1% typical) (for example, @1000 nm, resolution is <12.5 nm)

Analog-to-digital convertor

16 bit

Dynamic range (Max)

1000:1

Measurement time (typical)

0.25 – 0.5 second

Integration time

10 ms typical, minimum 10 µsec, maximum limited by dark signal

Computer interface

USB 2.0

Spectrometer weight

318 g (11.2 oz)
With window collar: 368 g or (13 oz)

Size

45 mm diameter x 69 mm tall

Power

USB powered (<500 mA @5V)

Data format

Encrypted, Unsb, CSV, and SPC output

Operating system

Windows 8.1, 8, and 7

Software available

MicroNIR Pro standard, Unscrambler X Lite, MicroNIR Process

Operating temperature

0 – 40 deg C (non-condensing)

Enclosure

Stainless steel 316: dust and waterproof, sealed and cleanable to IP67 standard

Mounting

Adaptable stainless steel tri-clover mount, screw into welded flange